| Randall 2004-10-24, 7:11 pm |
| Hi,
I've received correspondence from the NPF regarding reactivating
sample collections for the National Tissue Bank. They won't be
looking so much for those of us with sib pairs and involved
parents. Like in the last study.
They'll want those of us with no other P affected
relatives.
If some of you want to donate to the NPF you can contact Liz
Horn, Ph.d. Director of Research
So keep up those donations to the NPF. $$$ greases the wheels.
And the NPF gives us the good stuff like this,
http://www.ncbi.nlm.nih.gov/entrez/...t_uids=14996755
The genetics of psoriasis, psoriatic arthritis and atopic dermatitis.
Bowcock AM, Cookson WO.
Department of Genetics, Pediatrics and Medicine, Washington University
School of Medicine, St Louis, MO 63110, USA.
bowcock@genetics.wustl.edu
Psoriasis and atopic dermatitis are chronic and relapsing inflammatory
diseases of the skin associated with various immunologic
abnormalities. Approximately 30% of psoriasis patients also have joint
involvement, indicative of psoriatic arthritis. Genes and environment
play a key role in the pathogenesis of these diseases. Genome-wide
linkage scans have identified multiple loci linked to each disease and
revealed overlap with psoriasis and atopic dermatitis susceptibility
loci on chromosomes 1q21, 3q21, 17q25 and 20p12. The genes from these
loci have not yet all been identified, or systematically tested for a
role in psoriasis and atopic dermatitis; however, these locations
suggest that some susceptibility factors lie within genes or gene
families with common effects upon epithelial immunity. A strong HLA
association is described for psoriasis, but not for atopic dermatitis.
Knowledge of the genetic factors leading to these diseases will lead
to an understanding of their variable age at onset, their waxing and
waning and the variability of body surface environment. The effect of
environmental triggers may also be understood once the altered
pathways are elucidated. Genes implicated so far in atopic dermatitis
are SPINK5, FcepsilonRI-beta and PHF11. Genes implicated in psoriasis
so far are HLA-C, SLC9A3R1, NAT9, RAPTOR and SLC12A8. Genetic
modifiers such as CARD15 may predispose to psoriatic arthritis.
PMID: 14996755
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As a note for those of you wondering if $$ for the NPF really helps.
Dr. Anne Bowcock (the above study) works directly with this tissue
bank and is instrumental in running down these genes for over the last
decade.
Trust her and the nPF with yours...
$$$ and P gene donations from us to cure us, seems smart to me.
randall
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