| george of the jungle 2005-08-26, 8:54 am |
| On Fri, 26 Aug 2005 02:38:56 -0400, Dave <dave@nospam.com> wrote:
>
>Link to citation:
><http://www.ncbi.nlm.nih.gov/entrez/...t_uids=16014752>
>
>========================================================
>J Pharmacol Exp Ther. 2005 Jul 13; [Epub ahead of print]
>
>Amphetamine treatment similar to that used in the treatment of adult
>ADHD damages dopaminergic nerve endings in the striatum of adult
>non-human primates.
>
>Mechan-Mayne A, Yuan J, Hatzidimitriou G, Xie T, Mayne A, McCann UD,
>Ricaurte GA.
>
>Johns Hopkins University.
>
>Pharmacotherapy with amphetamine is effective in the management of
>attention-deficit/ hyperactivity disorder (ADHD), now recognized in
>adults, as well as in children and adolescents. Here we demonstrate that
>amphetamine treatment, similar to that used clinically for adult ADHD,
>damages dopaminergic nerve endings in the striatum of adult non-human
>primates. Furthermore, plasma concentrations of amphetamine associated
>with dopaminergic neurotoxicity in non-human primates are on the order
>of those reported in young patients receiving amphetamine for the
>management of ADHD. These findings may have implications for the
>pathophysiology and treatment of ADHD. Further preclinical and clinical
>studies are needed to evaluate the dopaminergic neurotoxic potential of
>therapeutic doses of amphetamine, in children as well as adults.
>
>PMID: 16014752
>========================================================
>
>Have any of you seen a good (preferably peer-reviewed) paper that
>estimates a NOAEL dose of d-amphetamine in humans and provides an
>in-depth discussion of the extrapolation from animal studies on which
>it's based? None of the animal studies that I've read thus far provide
>justification for the current prescribing guidelines or the FDA's MRTD.
> Postmortem histopathological observations from former methamphetamine
>addicts are wholly unimpressive.
>
>Dave
Well, what are the symptoms of toxicity observed in primates and are
they observed in humans at theraputic doses. Are they observed in
meth abusers?
_g
|