| CaliforniaLyme 2005-10-30, 6:09 pm |
| 1: Neuropsychologia. 2005 Oct 24; [Epub ahead of print] Related
Articles, Links
Bilateral dorsolateral thalamic lesions disrupts conscious
recollection.
Edelstyn NM, Hunter B, Ellis SJ.
School of Psychology, university of Keele, Keele, Newcastle under Lyme,
Staffordshire ST5 5BG, UK.
In an earlier study we disputed the claim that the mediodorsal thalamic
nucleus is critical for familiarity. We reported patient (QX) who
showed a severe deficit in conscious recollection, and behavioural
problems (disinhibition, emotional lability) with relative sparing of
familiarity-aware memory following a left mediodorsal thalamic lesion.
More recent MR imaging has revealed that QX's lesions are more
extensive than previously reported and involve both dorsolateral
thalamic nuclei, and whilst there is evidence of left mediodorsal
thalamic damage, it is not the main focus of damage. This paper reports
a full analysis of QX's thalamic pathology alongside a more detailed
investigation of his recognition memory, using yes/no and forced-choice
procedures, and executive function. The results revealed impairments in
yes/no recognition and conscious recollection rates of famous, artist
and unknown names. In addition to the previously noted behavioural
disinhibition and emotional lability, a deficit in spontaneous planning
ability was evident on the Zoo Map Test (subtest of the Bahavioural
Assessment of the Dysexecutive Syndrome). Forced-choice recognition,
familiarity estimates and remote memory showed higher levels of
preservation. The findings indicate that the dorsolateral thalamus is
part of the extended hippocampal circuit which is causally critical
only for recall and conscious recollection of complex associations
rather than for the more automatic processes linked with novelty
detection.
PMID: 16253293 [PubMed - as supplied by publisher]
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