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Home > Archive > Lyme Disease > October 2004 > Interrelations between fibromyalgia, thyroid autoantibodies, and depression.
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Interrelations between fibromyalgia, thyroid autoantibodies, and depression.
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| JWissmille 2004-10-24, 2:08 am |
| http://www.ncbi.nlm.nih.gov/entrez/...db=PubMed&list_
uids=15468372&dopt=Abstract
J Rheumatol. 2004 Oct;31(10):2036-40.
Interrelations between fibromyalgia, thyroid autoantibodies, and depression.
Ribeiro LS, Proietti FA.
From the Department of Rheumatology, Governador Israel Pinheiro Hospital, Belo
Horizonte, Brazil.
OBJECTIVE: To detect and quantify the association between fibromyalgia (FM) and
thyroid autoimmunity. METHODS: This cross-sectional study comprised 146 women
with FM and 74 case-controls, all 18 years of age or older. FM was diagnosed
according to the American college of Rheumatology 1990 classification criteria.
The Mini-International Neuropsychiatric Interview (MINI) was applied for the
diagnosis of depression, previously considered as an important confounding
factor. Thyroid autoimmunity was defined as the occurrence of detectable
antithyroid peroxidase antibodies and/or antithyroglobulin antibodies by the
immunometric assay. Cases of diffuse connective tissue diseases and thyroid
dysfunctions (hypo or hyperthyroidism) were excluded in both groups. RESULTS:
Univariate analysis detected an association between FM and thyroid autoimmunity
(odds ratio, OR = 3.87, 95% confidence interval, CI = 1.54-10.13), depression
(OR = 3.94, 95% CI = 1.97-7.93), and age (OR = 1.04, 95% CI =
1.01-1.07). In the final logistic regression model, after adjustment for
depression and age, the association between FM and thyroid autoimmunity was
strengthened (OR = 4.52, 95% CI = 1.86-11.0). CONCLUSION: Our results suggest
an association between FM and thyroid autoimmunity.
PMID: 15468372 [PubMed - in process]
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