Lyme Disease - doxy used for cancer in mice

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doxy used for cancer in mice

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2004-10-15, 4:06 am

Scientists find way to 'turn off' cancer

Antibiotic halts aggressive tumours in mice

Tim Radford, science editor
Monday October 11, 2004
The Guardian

Scientists in California have found a way to "turn off" a gene that
makes cancerous cells lethal. They eliminated aggressive, incurable
liver tumours in laboratory mice in four weeks, they report in an
advance paper in Nature today.

The study, based on a gene called Myc, could lead to new ways of
treating cancer.

Cancer Research UK scientists in Glasgow, working with colleagues in
Seattle, last year worked out the details of how Myc cranks up the
rate of growth of dividing cancer cells by sending one of the cell's
factories into overdrive. In cancer, cells divide uncontrollably.

The California team based their studies on mice with genetically
modified liver cells. The type of cell that becomes cancerous is
called an epithelial cell, and these form cancers in breast, colon and
prostate. So the same approach might work in all of them. Liver cancer
is common and difficult to treat.

"This is a terrible cancer. Anything that is encouraging in liver
cancer may be important," said Dean Felsher of Stanford University,
who led the research. "The exciting thing is that you can turn cancer
cells into something that appears to be normal."

The mice under study had a mutated Myc gene that was constantly on. It
produced a Myc protein that served as a kind of conductor, sending a
signal to cells to divide. Cancer cells produce too much Myc protein
all the time, and are constantly dividing. Dr Felsher and his
colleagues fed the mice an antibiotic called doxycycline, which turned
the gene off, and stopped the protein flow.

As long as the mice had the antibiotic diet, they remained healthy.
Once the antibiotic was withheld, they developed aggressive liver
cancer in 12 weeks. When they were put back on the diet, all of them
showed rapid regression: the liver cancer was eliminated, and liver
cells seemed to behave normally. In effect, the scientists turned the
Myc gene on and off like a tap, and turned cancer on and off at the
same time.

They also found that some of the apparently normal cells retained the
ability to become cancerous, which could explain why cancers often
recur after chemotherapy. Cancer hits one person in three, and kills
one in five. In recent years, researchers have concentrated on a
number of new approaches. They have tried to cut off the blood supply
to tumours, to halt their growth. They have tested search-and-destroy
toxins, designed to make for and eliminate only cancerous cells. They
have experimented with scalpels made of ultrasound, and they have
tried to "burn" cancerous cells with infrared radiation.

But cancer is, above all, a disease of the DNA, and British
researchers have launched a cancer genome project to collect all the
genetic mutations involved in the making of a cancer. There are more
than 100. But the Myc protein seems to play a role in many cases of
the disease.

The Glasgow study immediately suggested that it would be a good
target. If researchers could find a drug that blocked the action of
Myc, they could study its effect on cancer cases. The Stanford study
shows that they were right.

But what works in mice may not work so well in humans. The next step
is to hunt for a drug that would be safe for human patients, and yet
have the same impact.

derdrittemann

2004-10-15, 10:07 pm

"Frank de Groot" <franciad@online.no> wrote in message news:<Jx_ad.1831$rh1.40675@news2.e.nsc.no>...
> "derdrittemann" <derdrittemann2003@yahoo.com> wrote in message
>
"You are posting from Chicago, Illinois.
> And you don't pay tax, XXXXX"?

LOL!

I may well be "posting" from Chicago...now...I ask you...does that
mean that I necessarily live there? (hint...no, I do NOT. So, it
follows that I don't pay taxes there, either. I, ah, might know
someone who lives in Chicago, though. LOL. why do you waste your time
with this crap? There's about, I think, 5 million in the Chicago
area...good luck finding her)! Ah.

I think I see what you are trying to say, though...you are not saying
that I am philosophically supporting torture...just financially?
>
>
>
> "I will explain, XXXXX".

Have you ever considered that it just MIGHT not be in your best
interest to address people as "c--t", "b---h"... as it tends to
indicate a lack of respect for women...and I would think they are
certainly attuned to that fact.

Likewise, the constant use of "fool", "moron" and "imbecile", really
doesn't help your "thoughts" or arguments...just tends to show you as
the FOOL.
>
> "The US had a problem.
> They wanted to perform genocide on Iraq in order to be able to invade it a
> decade later (when Peak Oil was due), but they also desperately needed
> Iraq's oil".

Everyone wants that oil, Frank. You and some of your moralsitic
friends are the naive fools. No one really kills in the name of
God...they just encourage the masses to do it.

That oil...the wealth that comes from it...is what it is all about.
Yes, control of the oil.

What you don't seem to understand is that the opposition to the Iraqi
"adventure" wanted to keep control...which benefitted THEM. And they
have all this mass popular support for their corrupt agenda. They were
just defending their own staus quo...a corrupt and potentially
destructive arrangement with the devil.(small "d").

The irony is that the US has removed the lid of a pot that was
relatively secure. By removing Saddam...they have allowed their own
"nightmare scenario" to come true...Islamic fundamentalist control of
the oil is now possible, whereas it was not, under Saddam.

That'a why the beheadings...the terror...they want the US out so they
can control the oil. Fund their agenda. Wealth will maKe them VERY
powerful.
>
> "While hundreds of thousands of Itraqi's toddlers and babies were dying
> because of the Anglo-Saxon/Zionist genocide embargo, the French had the guts
> to stand up to the US and ask for "oil for food" (and medicine). The US
> thought that was OK because their gas price would go down and one and a half
> million kids had died already."

Naive and simplistically moralistic in the extreme. And wrong.

> "The US has killed 50,000 French citizens in the days of the Invasion of
> Normandy and they think France has forgotten that. France has a LOT of nukes
> and the ICBM's to deliver them richt to your doorstep, Nazi".

So...you think the Nazi occupation was a "good thing"?
>
> "And I am afraid the curtain
> will fall sooner rather than later, XXXXX."

It is interesting (and sad) to see how little you understand about
America and Americans.

Also how little you understand that the historical roots of European
greed, intrigue, colonialistic imperialism still continue to this day.

Too bad the real world isn't as "black and white" as you seem to
think.

..

Frank de Groot

2004-10-15, 10:07 pm

"derdrittemann" <derdrittemann2003@yahoo.com> wrote in message

> Have you ever considered that it just MIGHT not be in your best
> interest to address people as "c--t", "b---h"... as it tends to
> indicate a lack of respect for women...and I would think they are
> certainly attuned to that fact.
>
> Likewise, the constant use of "fool", "moron" and "imbecile", really
> doesn't help your "thoughts" or arguments...just tends to show you as
> the FOOL.

No it shows my lack of respect for fools, morons, imbecils, cunts and
bitches.

I understand why fools, morons, imbecils, cunts and bitches play the
"politically correct" card though. Trying to divide & conquer.

When a XXXXX is called a XXXXX, they will go to a good upstanding woman and
say: "Look, this guy degrades you as a woman so you have to stand up to
him".

Bullshit!

Frank de Groot

2004-10-15, 10:07 pm

"derdrittemann" <derdrittemann2003@yahoo.com> wrote in message

nukes[vbcol=seagreen]
>
> So...you think the Nazi occupation was a "good thing"?

Imbecile.
Sadly, the US has abolished history lessons.

France was siding with the Nazi's.
Meaning, the legitimate government of France (the Vichy government) was very
happy to become Nazi. In fact, France eagerly deported more Jews to the Nazi
death camps then the Nazi's demanded as minimum quota.

France surrendered because they WANTED to become "Nazi".

Now, what did the US do?
They barged into France, murdered tens of thousands of its citizens, ousted
the legitimate French goverment and committed countless war crimes.

I don't say the French government at the time was "good" (like Saddam's), I
just say that the US invaded a sovereign country of which its governemtn
opposed an invasion, proceeded to kill tens of thousands of innocent
civillians all to further the US's political goal of stopping communism
(Hitler was being overrun by the Russians and the US waited until that
happened, cleverly weakening both parties and Grampa Bush financing the
whole thing.).

derdrittemann

2004-10-15, 10:07 pm

"Frank de Groot" <franciad@online.no> wrote in message news:<5RCad.1644$rh1.28986@news2.e.nsc.no>...
>

> "The doxy I take is intended for horses and I fare well on it".

Seems to affect your mental processes...at least to the extent they exist.

Not surprised to hear you are taking horse medicine.

I always thought you were one end of a horse.

Frank de Groot

2004-10-17, 7:09 pm

"derdrittemann" <derdrittemann2003@yahoo.com> wrote in message

> You do understand, don't you, that France declared war on
> Germany...don't you?

A mere administrative formality by a minority government, not unlike how he
Spanish were overwhelmingly opposed to the genocidal attack on Iraq but
their corupt puppet govt. went along with the ZioNazi US regime regardless.

> Takes a lot of Gaul to defame the Franks that way, Frank.

HAHAHA
Like you could care less.
As long as you have SOMETHING to attack "Lyme is a chnonic disease and needs
long-term abx".
Now it's "Frank defames the French" LOL.

France, we're talking about the biggest thugs. It was the French that did
surface nuclear tests recently, destroying entire tropical paradise, it were
the French that assasinated David Kelley and it were the French that killed
Greenpeace activists when they bombed their ship.

And just 48 hours ago you hypocritical XXXXX, you were accusing the French
of being blackmailed by Saddam. But now it's poor French discredited by bad
Frank, LOL.

> You statement concerning French willingness to become "Nazi" is
> appalling and disgraceful. An horrible insult to those who died in the
> resistance.

HAHAHA
Like if you cared.

> Yes, there were fascist collaborators...in France and in
> Norway. But it is an awful thing to say...to dishonor the French who
> fought for liberte...and died doing it...as well as the American and
> British who paid the ultimate price.

Like you give a shit.
Tell me, where are your roots?
Ethnically?

Hehe..

[vbcol=seagreen]

YOU need to be ashamed, XXXXX.

Frank de Groot

2004-10-18, 7:09 pm

"derdrittemann" <derdrittemann2003@yahoo.com> wrote in message

> Seems to affect your mental processes...at least to the extent they exist.

No argument.

> Not surprised to hear you are taking horse medicine.

So?
It's 10 tims cheaper and readily available.
Why would I be a moron and pay 10 times more or take nothing?
Imbecile.

> I always thought you were one end of a horse.

And entire countries (like e.g. Norway) are now putting full-page messages
in US newspapers denouncing the US Nazi torture governent which you support:

http://www.tellhim.no/dokumenter/annonse.pdf

derdrittemann

2004-10-18, 7:09 pm

"Frank de Groot" <franciad@online.no> wrote in message news:<vSbbd.1812$Km6.44412@news4.e.nsc.no>...
> "derdrittemann" <derdrittemann2003@yahoo.com> wrote in message
>

> "France was siding with the Nazi's.
> Meaning, the legitimate government of France (the Vichy government) was very
> happy to become Nazi. >
> France surrendered because they WANTED to become "Nazi".

That's one of the dumbest pieces of crap I believe I have ever heard.
You do understand, don't you, that France declared war on
Germany...don't you?

Takes a lot of Gaul to defame the Franks that way, Frank.

Yes,...the Nazis attacked Poland September 1, 1939. Britain and France
honored mutual defense pacts with Poland...although they made
virtually no effort to stave off the Nazi occupation of Poland that
followed. France was then blitzkrieged into submission.

You statement concerning French willingness to become "Nazi" is
appalling and disgraceful. An horrible insult to those who died in the
resistance. Yes, there were fascist collaborators...in France and in
Norway. But it is an awful thing to say...to dishonor the French who
fought for liberte...and died doing it...as well as the American and
British who paid the ultimate price.
>
>You ought to be deeply ashamed...although I doubt that you will be.

Frank de Groot

2004-10-19, 11:08 am

"derdrittemann" <derdrittemann2003@yahoo.com> wrote in message

>I support "US Nazi torture"?
> This is news to me. Why? because I was born in the US? That's logical.

You are posting from Chicago, Illinois.
And you don't pay tax, XXXXX?

> Hey...did you see that stuff about how a UN official who is close to
> Chirac has sort of been implicated in a scheme of ripping off big
> bucks from the UN "Food for Oil" program?

I will explain, XXXXX.

The US had a problem.
They wanted to perform genocide on Iraq in order to be able to invade it a
decade later (when Peak Oil was due), but they also desperately needed
Iraq's oil.

While hundreds of thousands of Itraqi's toddlers and babies were dying
because of the Anglo-Saxon/Zionist genocide embargo, the French had the guts
to stand up to the US and ask for "oil for food" (and medicine). The US
thought that was OK because their gas price would go down and one and a half
million kids had died already.

The US thought it wouldn't matter much anyway because of the enriched
Uranium/Plutonium contaminated DU - genocidal radiation attacks on Iraq that
would finish the extermination job in a few generations.

Suddenly, right before the US Reichs-election the Americunt Republicunt
Neo-con Zionist genocidal Nazi's invent a "oil for food scam". Don't know
what they want to achieve by it..

What else do they want? Iraq has been genocidally cleansed by a second
nuclear war of reactor waste contamination and thousands of its
intelligensia has been assassinated, the US/UK/Zion alliance has blown up
the UN, now the only threat seems to be France, and the silly US thinks that
they can XXXX with France.

The US has killed 50,000 French citizens in the days of the Invasion of
Normandy and they think France has forgotten that. France has a LOT of nukes
and the ICBM's to deliver them richt to your doorstep, Nazi.

XXXX with the EU and multi-Megaton thermonuclear Hydrogen fusion bombs will
be raining on your parade. The world has changed. You can bully the world
only so far and then it's end of story for you. And I am afraid the curtain
will fall sooner rather than later, XXXXX.

Frank de Groot

2004-10-19, 7:14 pm

Frank de Groot

2004-10-20, 7:07 am

"derdrittemann" <derdrittemann2003@yahoo.com> wrote in message

> (Did you look into what I was telling you about low doses of
> beta-blocker controlling your rapid heartbeat? Take a look at
> it...better yet, see a doctor about it).

Fool.
When I was in the emergency room, they handed me a prescription for a beta
blocker for a pulse of 180. I said: "If my fast heartbeat is the result of
certain problems like nerve damage or cardiomyopathy, would it be possible
that a beta blocker could make it worse? Uh.. "Yeah..". Good! I snatched the
prescription and said: "I will use this as evidence in a malpractice suit".

Beta blockers don't work against neurally medicated vasospasms, moron.

> Oui, mon ami.

I'm not your ami, queer faggot skirt-wearing Scottisch homo.

> You seem to equate the actions of the French government with the
> entire populace. I notice that you do this with Americans also.

It's a democracy, ain't it?
So I can at least assume that 70% of the plebs rabidly support whatever
their gummint does.

You gotta have a few screws loose when you get yourself killed in the
process of killing people that happen to cross some imaginary line that the
gummint says: "That's ours or we'll shoot you".

Wars are bullshit. No need to participate in them.
Just walk away when gummints get crazy.
[vbcol=seagreen]
> I do. I regard WWII as a valiant struggle against tyranny...whether
> fascist or socialist..."vox populi"...that's the deal. Fight and die
> for liberte, egalite, fraternite. That's my opinion.

Yeah.
Go fight & die then, go on!
Fight (and hopefully die so we are rid of you) for our freedom to order meds
from abroad or something.

> Since you ask...and I have actually made reference to this several
> times...the genetic material comes from the North of Britain, mostly.
> Scots protestants. What are called "border" people. Some call them
> "Scots-Irish". One contemporary Englishman called them, "the worst
> scum of two nations". Many Americans have roots there.

Well you are certainly the worst scum of this newsgroup.

> I have no idea what that is supposed to mean. If you are thinking that
> I am German...you are WAY off base.

Why the XXXX would I think that with so many mistakes in your German?
Who do you think I am? Some kind of dumb XXXX?
You sure behave that way.

> "der dritte Mann" is simply a
> reference to the movie "The Third Man"...

Whatever.
Around here we consider anyone who hides behind a screen name to be a
malicious troll. Many people in Norway even put their entire address + tel.
nr. in their sig. Thousands of people here even have links to online
dictionaries with photo. Scum like you are nothing more than cowardly
trolls.