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Arthritis and multiple sclerosis running rampant thru my body
|
|
| fkissam 2005-05-24, 10:46 pm |
| I have excruciatign arthritis running thruout my body and I'm in the late
beginning stages of multiple sclerosis.
Can people guide me how to treat these things. The doctors have not been
too helpful.
Thank you.
| |
| Gary Stone 2005-05-25, 8:46 am |
|
"fkissam" <fkissam@bellsouth.net> wrote in message
news:bsSke.6859$6k7.4976@bignews4.bellsouth.net...
>I have excruciatign arthritis running thruout my body and I'm in the late
> beginning stages of multiple sclerosis.
>
> Can people guide me how to treat these things. The doctors have not been
> too helpful.
>
> Thank you.
>
>
I'm on so many pain pills, my dentist won't give me anything when he's done
with me. Naproxen is what they give me for it, I think it's available over
the counter as "Aleve". Might want to check to see if it's ok with whatever
else you're taking though.
Gary
| |
| ironjustice@aol.com 2005-06-12, 5:46 pm |
|
fkissam wrote:
> I have excruciatign arthritis running thruout my body and I'm in the late
> beginning stages of multiple sclerosis.
>
> Can people guide me how to treat these things. The doctors have not been
> too helpful.
>
> Thank you.
Arthritis is closely related to elevated iron levels .. in fact one of
the most
recent studies has found iron in the joints of those with rheumatoid
arthritis.
Annals of the Rheumatic Diseases 2002;61:741-744
Iron deposits may damage joint tissue in RA
Our understanding of the role of iron in rheumatoid arthritis (RA) has
improved
with a recent study showing where iron accumulates in the synovial
membranes
of affected joints. The researchers speculate how iron might build up
to toxic
amounts.
Ferritin, both light and heavy subunits , was found in the lining layer
and
subintimal zone of the synovium and in synovial macrophages and
fibroblasts.
Transferrin receptor appeared only in the lining layer .
Non-specific resistance associated macrophage proteins (Nramp) were
also found
.. These are proteins that span membranes and transport divalent
cations. Nramp
2 occurred in the macrophages and fibroblasts. Nramp 1 was present in
macrophages and neutrophils, in the synovial lining layer and the
subintimal
zone, and in infiltrating inflammatory cells, but not in fibroblasts.
The study used synovial membranes from arthroplasties of 20 patients
with RA.
Thin sections were stained cytochemically for ferritin, transferrin
receptor ,
and Nramp 1 with monoclonal or polyclonal antibodies. Macrophages and
fibroblasts were isolated from collaginase digests of synovial
membranes.
Neutrophils were isolated from synovial fluid aspirated routinely from
the
joints . These cell types were stained for ferritin and transferrin
receptor
immunocytochemically. Nramp 1 and Nramp 2 were identified by reverse
transcriptase polymerase chain reaction.
A high iron content has been noted in synovial membraines in RA , but
the
uptake and storage of iron and its potential relation to imflammation
of the
joints has been unknown until now.
http://tinyurl.com/7axjx
Ann N Y Acad Sci. 2004 Mar;1012:252-266. Related Articles, Links
The Role of Iron in the Pathogenesis of Experimental Allergic
Encephalomyelitis
and Multiple Sclerosis
http://tinyurl.com/bx6kv
Apoferritin Attenuates Experimental Allergic Encephalomyelitis
http://tinyurl.com/9wfa2
New Pain Therapy Reverses Glial Activation
By medinews.com staff writers
Posted on 17 December 2003
Iron Reduction Therapy - inexpensive antioxidant treatment.
http://herbivore.7h.com/depriv.html
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
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| |
| spodosaurus 2005-06-13, 8:46 am |
| ironjustice@aol.com wrote:
>
> fkissam wrote:
>
>
>
> Arthritis is closely related to elevated iron levels .. in fact one of
> the most
> recent studies has found iron in the joints of those with rheumatoid
> arthritis.
>
No shit, sherlock. I guess it's those micro bleeds (leakage) resulting
from chronic inflamation due to autoimmune attack (you know, that little
thing that actually causes rheumatoid arthritis which you haven't the
capacity to understand). Stop the inflamation, you stop the leakage, and
you don't end up with iron in the joints from blood. However, depriving
yourself of iron while on the medications to stop the inflamation is a
moronic thing to do, which I guess is why you suggest it. You see, these
medications not only retard the autoimmune attack they also suppress the
bone marrow, which can in some people lead to lower blood cell
production. The last thing they need is to further hinder their marrow
funciton by creating a state of iron deficiency anaemia. But you
wouldn't be able to understand any of this, because you have no idea
what you're talking about, you just cut and paste things you find on the
internet without having an inkling of what they mean or how they fit
into the larger picture of disease management. Now it's your turn to do
your Willam Shatner impression and start typing like Captain Kirk. Tell
me, have you been able to recruit another member to join you in your
cult yet, or are you still all alone?
Cheers!
Ari
--
spammage trappage: replace fishies_ with yahoo
I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/
| |
| ironjustice@aol.com 2005-06-13, 8:46 am |
| So .. THAT .. is .. YOUR .. 'contribution' ..
Eh ..
You didn't even open your mouth .. WHEN .. the poster .. asked for
input ..
But .. when 'input' .. IS .. provided .. WITH .. medical studies .. YOU
..=2E 'contribute' ..
Eh ..
Keep your 'contributions' .. to .. yourself ..
You 'know' .. something .. MORE .. than .. me ..
Do .. ya ..
You have 'some success' .. and THEN .. open your stupid fkg .. trap ..
UNTIL .. then ..
Just .. S-T-F-U ..
Do some .. oxy ..
Just .. stfu ..
>
..According to the article below .. iron reduction in THIS disease ..
leads to ..
IMPROVED .. anemia ..
So .. according to THIS article .. anemia .. does NOT .. necessarily ..
mean ..
iron deficiency ..
So since iron has been implicated IN the CAUSE of .. diabetes .. and
since
anemia is ONE of your .. problems .. then .. as I said before .. epogen
/
erythropoeitin is NOT .. necessarily .. your ONLY .. option ..
One might .. consider .. the effect of iron reduction .. as evidenced
..=2E below
..=2E
REDUCTION .. of .. anemia ..
GuyClin Exp Rheumatol. 1986
Jan-Mar;4(1):25-9. Related Articles, Links
Antianemic and potential anti-inflammatory activity of desferrioxamine:
possible usefulness in rheumatoid arthritis.
Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
In order to study the role of excessive synovial iron sequestration in
the
production of anemia in rheumatoid arthritis (RA), the antianemic
efficacy and
anti-inflammatory effect of desferrioxamine administered in a
short-term
treatment (14 days), were evaluated in 10 patients suffering from
classic or
definite RA and hyposideremic anemia. Treatment with desferrioxamine
showed an
elevated urinary iron excretion, a significant increase of serum iron,
UIBC and
hemoglobin, and a marked progressive decrease of serum ferritin. A
moderate
improvement of the pain intensity, morning stiffness and Ritchie's
index was
also observed. The results obtained suggest that excessive
reticuloendothelial
iron deposits occur in RA and that the iron uptake can be an important
factor
in the production of anemia. Desferrioxamine seems to be useful in the
treatment of patients suffering from RA and anemia, in order to release
iron
from synovial tissue, reduce the inflammatory process and improve
anemia,
changing an anemia which is typically resistant to the martial therapy
into an
iron-sensitive anemia.
Publication Types:
Clinical Trial
PMID: 3516495 [PubMed - indexed for MEDLINE]
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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/iron=ADju...adpeoplewalking <
..
| |
| ironjustice@aol.com 2005-06-13, 8:46 am |
| >Med Hypotheses 2001 Jul;57(1):120-2
Iron(III)-mediated intra-articular crystal deposition in arthritis: a
therapeutic role for iron chelators.
Naughton DP
School of Pharmacy and Biomolecular Sciences, university of
Brighton,
Cockcroft Building, Moulsecoomb, Brighton, UK.
D=2EP.Naugh...@bton.ac.uk
Crystal deposition in arthritic diseases has attracted much
interest.
Many reports have established the presence of calcium pyrophosphate
(CPPD), hydroxyapatite (HAP) and urate crystals throughout the range
of arthritic diseases. In particular, HAP crystals have been
detected
in 30-60% of synovial fluid (SF) samples from patients suffering
from
osteoarthritis (OA) and 33% of those suffering from rheumatoid
arthritis (RA). In OA, crystal deposition has been linked to greater
joint deterioration. The mechanism of intra-articular calcification
is
unknown. Nucleation is required to transform a 'metastable'
phosphate-
and calcium-rich biofluid into one that generates crystals. Ferric
ions have been demonstrated to induce crystallization of these
stable
supersaturated solutions via the process of nucleation.The inflamed
arthritic joint is prone to iron loading. Microbleeding from
compromised vasculature contributes to intra-articular iron loading
in
arthritic conditions. Low-molecular-mass redox-active iron complexes
have been detected in SF in inflammatory joint diseases. These
species
are credited with mediating oxidative stress via interaction with
peroxides and superoxide. In addition, adventitious
low-molecular-mass
iron complexes can cause nucleation leading to crystal growth within
the joint.Decorporating agents capable of removing this misplaced
iron
from the arthritic joint would have the joint benefit of relieving
oxidative stress and preventing crystal nucleation. Systemic side
effects could be overcome by the targeting suitable chelators using
bioreductive delivery systems that are activated in hypoxic inflamed
synovial tissue. Copyright 2001 Harcourt Publishers Ltd.
PMID: 11421639, UI: 21317021
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Rheumatol Int 1996;16(2):45-8
Effects of desferrioxamine therapy on chronic disease anemia associated
with
rheumatoid arthritis.
Salvarani C, Baricchi R, Lasagni D, Boiardi L, Piccinini R, Brunati
C,
Macchioni P, Portioli I
2Divisione di Medicina, Azienda Ospendaliera Arcispedale S. Maria
Nuova, Reggio Emilia, Italy.
OBJECTIVE: To investigate the effects of desferrioxamine (DFO)
infusion on chronic disease anemia (CDA) of rheumatoid arthritis
(RA)
by evaluating interleukin-6 (IL-6) and erythropoietin (EPO)
production. PATIENTS AND METHODS: Five patients with RA and CDA
(group
I) were treated with DFO, 500 mg daily, through a continuous 10-h
subcutaneous infusion 5 days a week for 4 weeks. One month after
withdrawal, DFO was resumed in all five group I patients (group II)
with an increase to 1 g daily following the previous treatment
schedule. Clinical and laboratory parameters were evaluated weekly
during the two study periods. Serum EPO was measured by
radioimmunoassay. IL-6 was detected by the enzyme-linked
immunoabsorbent assay method. RESULTS: No significant variations in
hematological parameters, IL-6 or EPO levels were observed in group
I
patients. After 1 week of DFO 1 g daily, reticulocyte counts and EPO
improved significantly. Hemoglobin and hematocrit rose significantly
after 3 weeks of 1 g daily DFO therapy. Four weeks after DFO
withdrawal, EPO, reticulocyte counts, hemoglobin and hematocrit
returned to baseline levels. A significant improvement in the
clinical
parameters of disease activity was observed, particularly in group
II
patients. CONCLUSION: DFO improves CDA in RA patients. The
beneficial
effects on erythropoiesis seem to be related to improved EPO
responsiveness to the anemia.
PMID: 8853224, UI: 97005925
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| |
| ironjustice@aol.com 2005-06-13, 8:46 am |
| > Ann Rheum Dis 1989 May;48(5):382-8
Investigation of the anti-inflammatory properties of
hydroxypyridinones.
Hewitt SD, Hider RC, Sarpong P, Morris CJ, Blake DR
Cancer Research Unit, university of York, Heslington.
Synovial iron deposition associated with rheumatoid disease may
result
in the production of highly reactive oxygen free radicals, leading
to
tissue damage. This chain of events can be interrupted by iron
chelation. Families of strong iron (III) chelators have been tested
for their iron scavenging properties in vitro and their effects
assessed in vivo using a rat model of inflammation. All the
chelators
competed successfully for iron with apotransferrin, and some removed
up to 34% of iron from ferritin. The best anti-inflammatory effects
were achieved with the most hydrophilic chelators and those which
chelated iron most avidly. Activity was dependent on dose. The route
of administration was also an important factor with lower affinity
chelators. This work introduces a range of simple bidentate iron
chelators, which under certain conditions exceed desferrioxamine in
their iron scavenging abilities, and some of which, in this simple
animal model, approach indomethacin in their anti-inflammatory
capabilities.
Comments:
* Comment in: Ann Rheum Dis 1990 Nov;49(11):956-7
PMID: 2730166, UI: 89272259
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Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
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DEAD PEOPLE WALKING
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<
| |
| ironjustice@aol.com 2005-06-13, 8:46 am |
| Daily News
Vegan Diet Improves Rheumatoid Arthritis Symptoms
11/14/02 - Healthnotes Newswire=97A strict vegetarian diet led to
improvement
in symptoms of rheumatoid arthritis (RA), according to a clinical trial
published in Rheumatology (2001;40:1175=969).
Thirty-eight people with rheumatoid arthritis were assigned to consume
a vegan
diet (a vegetarian diet that also excludes dairy products and eggs) and
also to
avoid gluten-containing grains (wheat, oats, barley, and rye) for one
year.
Twenty-eight other people with RA were assigned to eat a more typical
unrestricted diet, including meat (control group).
Only 22 of the 38 people assigned to eat the vegan diet completed at
least nine
months of the dietary intervention. Of those, 40% (nine people)
experienced
improvement in the symptoms of RA compared with only 4% (one person) in
the
group eating the standard diet.
RA is one of a group of conditions called autoimmune diseases. In
autoimmune
disease, the body=92s immune system, which is designed to fight off
infectious
agents and other foreign substances, mistakenly attacks its own
tissues. In RA,
the autoimmune damage is to the joints, but other tissues and organs
are
frequently affected as well. Conventional therapy includes drugs that
reduce
inflammation or suppress the immune system. Surgery may also be
recommended, if
the joint damage is severe. While these treatments are often helpful,
many
individuals with RA continue to experience symptoms. Moreover, drugs
used to
treat RA can cause significant side effects, ranging from bleeding
peptic
ulcers to bone marrow damage. Any safe treatment that might help
relieve
symptoms of RA would, therefore, be welcomed.
There are several possible explanations for the improvements seen in
this
study. Meat is high in a specific fatty acid (arachidonic acid) that is
believed to promote inflammation in the body. Because vegetarian diets
contain
less arachidonic acid than omnivorous diets, consuming a vegetarian
diet might
produce an anti-inflammatory effect. Another possible explanation for
the
improvement is that plant-based diets are high in certain
anti-inflammatory
compounds such as essential fatty acids and enzymes. Finally, the
results may
be attributable in part to the avoidance of common food allergens, such
as
wheat and dairy products. Although the relationship between food
allergy and
arthritis remains controversial, a growing body of evidence suggests
that
allergy is a contributing factor, at least in a minority of individuals
with
RA.
Other natural treatments that have been reported to be helpful for
people with
RA include zinc, borage oil, black currant seed oil, and fish oil.
Individuals
with RA who wish to pursue the dietary or nutritional-supplement
approach
should consult a doctor knowledgeable in natural medicine.
=97Matt Brignall, N.D.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
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| |
| ironjustice@aol.com 2005-06-13, 8:46 am |
| >
I suppose this give a bit of credence to this hypothesis as to the
'true' workings of aspirin .. as a chelator of .. iron ..?
http://news.excite.com/news/r/=AD010928/18/health-iron
Iron Imbalance in Brain May Cause Migraine
Updated: Fri, Sep 28 6:22 PM EDT
By Will Boggs, MD
NEW YORK (Reuters Health) - Abnormalities in the way the brain's
pain
control center handles iron may lead to the development of migraine
attacks and headaches, according to a study by Kansas researchers.
During migraine, a portion of the brain known as the periaqueductal
gray matter (PAG) may fail to "switch on" to prevent pain, Dr. K.
Michael Welch of the university of Kansas Medical Center in Kansas
City told Reuters Health.
"In migraine, a trigger such as stress activates the PAG but it does
not switch on because it is dysfunctional," he explained, "or else
switches on an abnormal part."
The result? "Pain instead of no pain," according to Welch.
His team studied levels of iron in the PAG of patients with either
migraine headaches or recurrent, non-migraine headaches and compared
them to levels in people without headache or migraine.
Changes in iron levels can reflect changes in the way the cells of
the
PAG work, the authors pointed out.
According to the report, published in a recent issue of the journal
Headache, iron levels in the PAG were significantly increased in
patients with migraine and those with headache compared to the
headache-free group.
In fact, the researchers pointed out, the longer patients had
experienced headaches, the higher the iron levels in the PAG were,
though iron levels at the beginning of their illness were still
clearly higher than normal.
Increased iron levels may be both a cause of migraine attacks and a
result of repeated headaches, the investigators noted.
"Thus, we believe that the increased (iron levels) in our migraine
groups reflect impaired iron (balance), possibly associated with
(nerve) dysfunction or damage," the authors concluded.
"Perhaps the PAG abnormality is essential to the cause of the
headache
in migraine," Welch said. "The gradual deposition of iron increases
dysfunction, and headaches coalesce from episodic to continuous."
How, then, might one minimize the damage from increased iron stores?
Welch advised, "Treat episodes quickly and prevent (attacks)
whenever
possible."
SOURCE: Headache 2001;41:629-637.
Email this story | Printer-friendly version
Subject: chelate/aspirin
Med Hypotheses 1998 Mar;50(3):239-51
A chelate theory for the mechanism of action of aspirin-like drugs.
Wang X
Department of Pathology, Cornell university Medical College, New
York,
NY 10021, USA. x...@mail.med.cornell.edu
Two hundred years after the discovery of the pharmaceutical
usefulness
of aspirin, it and aspirin-like drugs, a family with an
ever-increasing number of members, are an indispensable part of
modern
life. However, the question as to how these drugs work in the body
has
remained unsettled. It is postulated here that this group of drugs
may
exert their therapeutic (and adverse) effects by chelating various
physiologically important metallic cations in the body. The chelate
theory is supported by the vast majority, if not all, of the
observations on these drugs made in the past.
Publication Types:
* Review
* Review, academic
PMID: 9578329, UI: 98237440
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Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
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<
| |
|
|
| ironjustice@aol.com 2005-06-13, 8:46 am |
| http://www.bufflink.org/NewsText/379426443981482.html
Multiple Sclerosis Tied to Iron in Brain
Studies Point to Cause, Location of MS Brain Damage
By Daniel DeNoon
WebMD Medical News
Reviewed By Brunilda Nazario, MD
on Wednesday, October 22, 2003
Oct. 22, 2003 -- Iron deposits deep in the brain may cause multiple
sclerosis, new imaging studies suggest.
The findings come from studies of computer-assisted brain scans using a
specialized magnetic resonance imaging (MRI) device. university at
Buffalo, N.Y., researchers Rohit Bakshi, MD, and colleagues are the
first to use this technique to study multiple sclerosis. Bakshi
reported the findings at this week's annual meeting of the American
Neurological Association in San Francisco.
Multiple sclerosis has been considered a disease of the white matter in
the brain and spinal cord -- the neural pathways that allow areas of
gray matter to communicate with one another. But the new findings link
iron deposits in the gray matter to movement and thinking impairments
in multiple sclerosis.
"If we're going to treat this disease, we have to know where the damage
is," Bakshi says in a news release. "Traditionally, we thought MS was
strictly a white-matter disease. ... We were able to visualize gray
matter structures deep in the brain of MS patients and found some to be
atrophied."
These areas of brain damage contained abnormally high levels of iron.
It's not yet clear that the iron is the cause of the brain damage. It
could be that dying brain cells leave a trail of iron behind.
Walking, Thinking, and Gray Matter
Bakshi's team put 41 multiple sclerosis patients through a walking
test. They also gave tests of learning, speed of information
processing, and memory to 28 MS patients.
The more unnatural darkness the brain scans saw in a patient's gray
matter, the worse the patient's MS symptoms. It was the only factor
studied that independently predicted impaired walking and thinking.
"We suspect that MS patients have defective blood-brain barriers, the
cell layer that prevents potentially toxic substances from entering the
brain," Bakshi says. "Excessive iron entering the brain may damage the
deep gray matter structures."
Possible Treatment
If iron is indeed the culprit, it seems possible to do something about
it. Bakshi's team is exploring two ideas. The first is simply to remove
excess iron from patients' bodies, and then to devise a way to prevent
future iron build-up.
If that is impractical, it may be possible to prevent iron from killing
brain cells. The excess iron may be causing free radicals -- extremely
reactive molecules that damage brain cells. Antioxidants -- such as
vitamins C and E, or even more powerful agents -- might mop up free
radicals before they do their dirty work.
Even if the iron deposits are the effect, rather than the cause, of
brain cell death, the study still offers a way to measure the severity
of MS and the efficacy of new treatments.
---------------------------------------------------------------------------=
-----
SOURCES: American Neurological Association 128th Annual Meeting, San
Francisco, Oct. 19-22, 2003. News release, university at Buffalo, N.Y.
=A9 2003 WebMD Inc. All rights reserved.
=A9 2002 BuffLink, Inc. All rights reserved.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/iron=ADju...adpeoplewalking
| |
| spodosaurus 2005-06-13, 8:46 am |
| ironjustice@aol.com wrote:
> So .. THAT .. is .. YOUR .. 'contribution' ..
>
And so begins the Shatner-esque rant we've all grown to know and giggle
over :-) You're a joke, Tom. Go back to therapy and take your
medication, when you're well enough you'll actually be able to
contribute to society (I would have finished that sentence with 'again',
but I'm not so sure it would have been accurate).
Cheers!
Ari
--
spammage trappage: replace fishies_ with yahoo
I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/
| |
|
|
| spodosaurus 2005-06-13, 11:45 am |
| ironjustice@aol.com wrote:
> According to your sig line .. you don't pick your fights .. well ..
>
> Learn from it ..
>
> F-O ..
>
Unlike you Tommy, I actually put my money where my mouth is when it
comes to helping people. I guess a shut in (by choice) like yourself
wouldn't understand that (ignorance and cutting and pasting from what
other people have done doesn't really count, now does it, Tommy?). It's
nice to see that you're consistent, though: I wonder what we'd all do if
you ever learned how to speak in a way other than that of an old TV
sci-fi character. The results could be catastrophic!
Cheers!
Ari
--
spammage trappage: replace fishies_ with yahoo
I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/
| |
|
|
| kamel 2005-06-15, 11:49 am |
| "spodosaurus" <spodosaurus@_yahoo_.com> wrote in message :
> I'm going to die rather sooner than I'd like. I tried to protect my
> neighbors from crime, and became the victim of it. Complications in
> hospital following this resulted in a serious illness. I now need a bone
> marrow transplant. Many people around the world are waiting for a marrow
> transplant, too. Please volunteer to be a marrow donor:
> http://www.abmdr.org.au/
> http://www.marrow.org/
People with diseases such as MS are not accepted as blood donors, bone
marrow donors, blood cell donors and probably organ donors in general. I
was given a letter of rejection as soon as I was diagnosed with MS.
Because not enough is known about the etiology of MS, those gathering blood
for use on others should not endanger the lives of seriously ill or surgical
patients by supplying blood which could lead to another illness.
--
"spodosaurus" <spodosaurus@_yahoo_.com> wrote in message
news:42adb61f$1@quokka.wn.com.au...
> ironjustice@aol.com wrote:
>
> Unlike you Tommy, I actually put my money where my mouth is when it comes
> to helping people. I guess a shut in (by choice) like yourself wouldn't
> understand that (ignorance and cutting and pasting from what other people
> have done doesn't really count, now does it, Tommy?). It's nice to see
> that you're consistent, though: I wonder what we'd all do if you ever
> learned how to speak in a way other than that of an old TV sci-fi
> character. The results could be catastrophic!
>
> Cheers!
>
> Ari
>
> --
> spammage trappage: replace fishies_ with yahoo
>
> I'm going to die rather sooner than I'd like. I tried to protect my
> neighbours from crime, and became the victim of it. Complications in
> hospital following this resulted in a serious illness. I now need a bone
> marrow transplant. Many people around the world are waiting for a marrow
> transplant, too. Please volunteer to be a marrow donor:
> http://www.abmdr.org.au/
> http://www.marrow.org/
| |
| spodosaurus 2005-06-15, 11:49 am |
| ironjustice@aol.com wrote:
> THAT .. is .. it .. ?
>
> THAT .. is .. your .. 'contribution' ..?
>
> Attack the .. poster ..
>
> Heh .. heh ..
>
> You are some piece of work ..
>
> EVERY .. isp in the world says .. sht the fk up ..
>
> But ... youuuuuu ...
>
> Don't have to ..
>
> That must be because you are .. spodosaurus ..
>
> read my lips you two bit little jrkff ..
>
> You either begin to refute the medical studies .. supplied .. or ..
> attempt to .. at least ACT .. like a fkg .. man ..
Dear dear Tommy, you're getting spittle all over your 14" dusty old CRT!
My contributions are many, including original empirical research, but in
this case it's pointing out to those who may not know better (yet) that
you're a complete boob. I also clarified why you're a complete boob and
gave a brief explanation of your typical misunderstandings and invalid
assumptions. I understand the things you copy and paste as well as
understanding the interplay of factors involved. Unfortunately, you have
neither the grey matter nor the willpower to work through an education
in order to actually carry out any research, and this is why you copy
and paste things and proclaim 'look, studies!' when you haven't a clue
as to what these studies really mean, the populations to which they may
apply, or the various factors involved in the disease processes (nor do
you comprehend their interactions). All you do is type incorrectly
spelled obscenities in broken english with horrendous punctuation and
nothing original to offer: the rest is copy and paste from the people
who are really contributing empirical research. Unfortunately it seems
you'll have a hard time understanding what I've written, but that's your
choice, just like it's your choice to sit at home all day and do nothing
but try and recruit people to your lonely little cult without any chance
of success (and in this case it's not persistence on your part, it's
stupidity). You'll excuse me while I continue with my real work and try
to finish up a few projects that have been backlogged due to
hospitalisations (I'm sure you'll understand that much, having studied
my signature so intently). I await your next round of spew on the edge
of my seat, though I really shouldn't as it's inevitable: you haven't
the self control not to issue forth more vitriol from that murky
cesspool that resides within you and grows deeper by the day.
Cheers!
Ari
PS- I thought about paragraphing this post, but I decided against it as
it might prove too overwhelming for you. Best to try and get through to
you with a style you're more familiar with :-)
--
spammage trappage: replace fishies_ with yahoo
I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/
| |
| spodosaurus 2005-06-15, 11:49 am |
| kamel wrote:
> "spodosaurus" <spodosaurus@_yahoo_.com> wrote in message :
>
>
>
> People with diseases such as MS are not accepted as blood donors, bone
> marrow donors, blood cell donors and probably organ donors in general. I
> was given a letter of rejection as soon as I was diagnosed with MS.
>
> Because not enough is known about the etiology of MS, those gathering blood
> for use on others should not endanger the lives of seriously ill or surgical
> patients by supplying blood which could lead to another illness.
>
'Tis true, there are restrictions applied to who can be marrow donors
(covered in those sites I have listed in my signature - snipped in this
post to avoid redundancy). It would be unfortaunte to have a recipient
survive the dangers of a marrow transplant only to develop an auto
immune disease (beyond graft versus host disease) from the transplant
itself. There are also age restrictions on marrow donation, though these
may be waived in some special cases for specific recipients.
It's always exciting to watch new developments in MS (and other
illness) research but this has to be tempered with the knowledge that
often these discoveries are 5-10 years (minimum) from leading to an
implementation of a treatment.
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
| >People with diseases such as MS are not accepted as blood donors, bone
marrow donors, blood cell donors and probably organ donors in general.
I
was given a letter of rejection as soon as I was diagnosed with MS.
Because not enough is known about the etiology of MS, those gathering
blood
for use on others should not endanger the lives of seriously ill or
surgical
patients by supplying blood which could lead to another illness
<
It is a matter of convincing the doctor that a level of . NID / near
iron deficiency .. is NOT .. harmful .. and .. possibly is .. HELPFUL
...
Since there are researchers who believe oxidative stress IS .. involved
IN .. the pathogenesis OF .. both .. MS and arthritis .. then it would
take some articles .. such as the aspirin .. article .. to convince the
doctor elevated / unbound iron 'might' .. be .. involved.
And since there ARE researchers who believe a little anemia / iron
deficiency .. "never hurt nobody" .. then studies which SHOW pain
killers work BY .. binding of iron .. combined WITH studies which show
... iron .. TO BE .. 'there' .. might entice the / your doctor to
attempt a little 'heroic medical intervention' .. ?
As in the testing of .. NID / near iron deficiency ..
Throw in the .. "minocycline ..is an iron chelator" .. and .. ??
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
| Rheumatology (Oxford). 2003 Dec;42(12):1550-5. Epub 2003 Jun 27.
Related Articles, Links
Near-iron deficiency-induced remission of gouty arthritis.
Facchini FS.
Department of Medicine, San Francisco General Hospital and University
of California San Francisco, 94143, USA. fste2000@yahoo.com
OBJECTIVES: Previous evidence supports a role for iron in the
pathogenesis of gout. For example, iron, when added to media containing
urate crystals, stimulated oxidative stress with subsequent complement
and neutrophil activation. Conversely, iron removal inhibited these
responses as well as urate-crystal-induced foot pad inflammation in
rats in-vivo. The objective of the present study was to investigate
whether or not iron removal may improve the outcome of gouty arthritis
in humans as well. METHODS: Quantitative phlebotomy was used to remove
iron in 12 hyperuricaemic patients with gouty arthritis and maintain
their body iron at near-iron deficiency (NID) level (i.e. the lowest
body iron store compatible with normal erythropoiesis and therefore
absence of anaemia). RESULTS: During maintenance of NID for 28 months,
gouty attacks markedly diminished in every patient, from a cumulative
amount of 48 and 53 attacks per year before (year -2, -1), to 32, 11
and 7 during induction (year 0) and maintenance (year +1, +2) of NID,
respectively. During NID, attacks were also more often of milder
severity. CONCLUSIONS: During a 28-month follow-up, maintenance of NID
was found to be safe and beneficial in all patients, with effects
ranging from a complete remission to a marked reduction of incidence
and severity of gouty attacks.
Publication Types:
Clinical Trial
PMID: 12832712 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
| J Clin Apheresis. 2002;17(2):88-92. Related Articles, Links
In hereditary hemochromatosis, red cell apheresis removes excess iron
twice as fast as manual whole blood phlebotomy.
Muncunill J, Vaquer P, Galmes A, Obrador A, Parera M, Bargay J,
Besalduch J.
Fundacio Banc de Sang i Teixits de les Illes Balears, Palma de
Mallorca, Spain. jmuncunill@retemail.es
The current treatment of hereditary hemochromatosis (HH) consists of
performing periodic manual whole blood phlebotomies. Erythroapheresis
(EPH) is considered to be an alternative procedure if the classic
treatment is contra-indicated. A prospective study of 13 consecutive
cases of HH were included in a periodic EPH program with the aim of
assessing the efficacy, feasibility, and tolerability of EPH in the
treatment of HH by induction and maintenance. Iron depletion (ferritin
<20 microg/l) was achieved in all patients after a mean of 6.7 +/- 2.9
months of treatment and a mean of 13.5 +/- 7.2 EPH sessions. The
procedure was well tolerated and there were no complications. After a
follow-up period of 10.5 +/- 6.6 months, only four patients have
required further maintenance sessions beyond 6 months after completing
the induction therapy. The efficacy, speed, tolerability, and more
favorable schedule of an EPH program facilitate treatment of HH.
Copyright 2002 Wiley-Liss, Inc.
Publication Types:
Clinical Trial
PMID: 12210712 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
|
>
<<snip>>
Our results implicate that flavonoids may be able to limit the
demyelination
process during multiple sclerosis.
<<snip>>
Fermented papaya preparation (50 mg/ml) scavenged 80% of hydroxyl
radicals
The oral administration of the fermented papaya preparation for 4 weeks
decreased the elevated of lipid peroxide levels in the ipsilateral 30
min after
injection of iron solution by iron into the left cortex of rats. The
fermented
papaya preparation also increased superoxide dismutase activity in the
cortex
and hippocampus of them. These results suggest that the fermented
papaya
preparation has antioxidant actions and that it may be prophylactic
food
against the age related and neurological diseases associated with free
radicals
<<snip>>
Biochem Pharmacol. 2003 Mar 1;65(5):877-85. Related Articles, Links
Flavonoids inhibit myelin phagocytosis by macrophages; a
structure-activity
relationship study.
Hendriks JJ, de Vries HE, van der Pol SM, van den Berg TK, van Tol EA,
Dijkstra
CD.
Department of Molecular Cell Biology, VU Medical Centre, Van der
Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
jja.hendriks.c...@med.vu.nl
Demyelination is a characteristic hallmark of the neuro-inflammatory
disease
multiple sclerosis. During demyelination, macrophages phagocytose
myelin and
secrete inflammatory mediators that worsen the disease. Here, we
investigated
whether flavonoids, naturally occurring immunomodulating compounds, are
able to
influence myelin phagocytosis by macrophages in vitro. The flavonoids
luteolin,
quercetin and fisetin most significantly decreased the amount of myelin
phagocytosed by a macrophage cell line without affecting its viability.
IC(50)
values for these compounds ranged from 20 to 80 microM. The flavonoid
structure
appeared to be essential for observed effects as flavonoids containing
hydroxyl
groups at the B-3 and B-4 positions in combination with a C-2,3 double
bond
were most effective. The capacity of the various flavonoids to inhibit
phagocytosis correlated well with their potency as antioxidant, which
is in
line with the requirement of reactive oxygen species for the
phagocytosis of
myelin by macrophages. Our results implicate that flavonoids may be
able to
limit the demyelination process during multiple sclerosis.
PMID: 12628496 [PubMed - indexed for MEDLINE]
------------------------------=AD------------------------------=AD---------=
-----
------
------------------------------=AD------------------------------=AD---------=
-----
------
1: Biochem Mol Biol Int. 1998 Jun;45(1):11-23.
Related Articles, Links
Free radical scavenging activity of fermented papaya preparation and
its effect
on lipid peroxide level and superoxide dismutase activity in
iron-induced
epileptic foci of rats.
Imao K, Wang H, Komatsu M, Hiramatsu M.
SAIDO Co., Fukuoka, Japan.
Fermented papaya preparation is a natural health food that has been
commercially sold in Japan for 2 years. It is made by yeast
fermentation of
Carica Papaya Linn. We examined the antioxidant action of the fermented
papaya
preparation on free radicals and lipid peroxidation. Free radicals have
been
related with aging and diseases, such as cancer, diabetes and
especially in
neurological disorders, for example, Parkinson's disease or Alzheimer's
disease. A diet including variable antioxidant foods may therefore help
to
prevent these illnesses. The free radical scavenging activity of the
fermented
papaya preparation was examined using an electron spin resonance (ESR)
spectrometer. Fermented papaya preparation (50 mg/ml) scavenged 80% of
hydroxyl
radicals (.OH) as spin adducts of spin trap,
5,5-dimethyl-1-pyrroline-N-oxi=ADde
(DMPO) (5.27 x 10(15)spins/ml) generated by Fenton reagents. The value
of IC50
was 12.5 mg/ml. The oral administration of the fermented papaya
preparation for
4 weeks decreased the elevated of lipid peroxide levels in the
ipsilateral 30
min after injection of iron solution by iron into the left cortex of
rats. The
fermented papaya preparation also increased superoxide dismutase
activity in
the cortex and hippocampus of them. These results suggest that the
fermented
papaya preparation has antioxidant actions and that it may be
prophylactic food
against the age related and neurological diseases associated with free
radicals.
PMID: 9635126 [PubMed - indexed for MEDLINE]
------------------------------=AD------------------------------=AD---------=
-----
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/iron=ADju...eoplewalking=20
<
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
| >
http://my.webmd.com/content/article/1827.50440
Antibiotic May Ease Multiple Sclerosis - WebMD Medical News
By Michael Smith, MD
WebMD Medical News
<<snip>>
Dec. 21, 2001 -- A common antibiotic is effective in calming
inflammation and preserving nerve function in animals with a disease
that mimics multiple sclerosis.
Minocycline is already used to treat several different infections, but
it's also effective in rheumatoid arthritis -- an inflammatory
condition. Because of this anti-inflammatory property, researchers gave
minocycline to rats with a disease that closely resembles the
inflammatory process of human MS.
<snip>>
Antimicrob Agents Chemother 2000 Mar;44(3):763-6
Iron-chelating activity of tetracyclines and its impact on the
susceptibility
of Actinobacillus actinomycetemcomitans to these antibiotics.
Grenier D, Huot MP, Mayrand D
Groupe de Recherche en Ecologie Buccale, Faculte de Medecine
Dentaire,
Quebec, Canada. Daniel.Gren...@greb.ulaval.ca
Three tetracyclines (tetracycline, doxycycline, and minocycline)
were
found to possess iron-chelating activity in a colorimetric
siderophore
assay. Determination of MICs indicated that the activity of
doxycycline against the periodontopathogen Actinobacillus
actinomycetemcomitans was only slightly influenced by the presence
of
an excess of iron that likely saturates the antibiotic. On the other
hand, the MICs of doxycycline and minocycline were significantly
lower
for A. actinomycetemcomitans cultivated under iron-poor conditions
than under iron-rich conditions.
PMID: 10681353, UI: 20145404
______________________________=AD______________________________=AD_____
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
<
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
| Magn Reson Imaging. 2005 Jan;23(1):1-25. Related Articles, Links
Imaging iron stores in the brain using magnetic resonance imaging.
Haacke EM, Cheng NY, House MJ, Liu Q, Neelavalli J, Ogg RJ, Khan A,
Ayaz M, Kirsch W, Obenaus A.
The MRI Institute for Biomedical Research, 440 East Ferry Street,
Detroit, MI 48202, USA. nmrimaging@aol.com
For the last century, there has been great physiological interest in
brain iron and its role in brain function and disease. It is well known
that iron accumulates in the brain for people with Huntington's
disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis,
chronic hemorrhage, cerebral infarction, anemia, thalassemia,
hemochromatosis, Hallervorden-Spatz, Down syndrome, AIDS and in the eye
for people with macular degeneration. Measuring the amount of nonheme
iron in the body may well lead to not only a better understanding of
the disease progression but an ability to predict outcome. As there are
many forms of iron in the brain, separating them and quantifying each
type have been a major challenge. In this review, we present our
understanding of attempts to measure brain iron and the potential of
doing so with magnetic resonance imaging. Specifically, we examine the
response of the magnetic resonance visible iron in tissue that produces
signal changes in both magnitude and phase images. These images seem to
correlate with brain iron content, perhaps ferritin specifically, but
still have not been successfully exploited to accurately and precisely
quantify brain iron. For future quantitative studies of iron content we
propose four methods: correlating R2' and phase to iron content;
applying a special filter to the phase to obtain a susceptibility map;
using complex analysis to extract the product of susceptibility and
volume content of the susceptibility source; and using early and late
echo information to separately predict susceptibility and volume
content.
PMID: 15733784 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
| Ann N Y Acad Sci. 2004 Mar;1012:252-66. Related Articles, Links
The role of iron in the pathogenesis of experimental allergic
encephalomyelitis and multiple sclerosis.
Levine SM, Chakrabarty A.
Department of Molecular and Integrative Physiology, Mental Retardation
and Human Development Center, university of Kansas Medical Center,
Kansas City 66160, USA. slevine@kumc.edu
Multiple sclerosis (MS) and its animal model, experimental allergic
encephalomyelitis (EAE), are autoimmune disorders resulting in
demyelination in the central nervous system (CNS). Pathologically, the
blood-brain barrier becomes damaged, macrophages and T cells enter into
the CNS, oligodendrocytes and myelin are destroyed, astrocytes and
microglia undergo gliosis, and axons become transected. Data from
several biochemical and pharmacological studies indicate that free
radicals participate in the pathogenesis of EAE, and iron has been
implicated as the catalyst leading to their formation. The primary
focus of this article is the examination of the role of iron in the
pathogenesis of MS and EAE. Particular attention will be paid to the
role and distribution of iron and proteins involved with iron
metabolism (e.g., transferrin, ferritin, heme oxygenase-1, etc.) in
normal and disease states of myelin. Furthermore, therapeutic
interventions aimed at iron, iron-binding proteins, and substrates or
products of iron-catalyzed reactions leading to free radical production
will be discussed.
Publication Types:
Review
PMID: 15105271 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| ironjustice@aol.com 2005-06-15, 11:49 am |
| Int J Vitam Nutr Res. 2005 Mar;75(2):119-25. Related Articles, Links
Caffeic acid inhibits oxidative Stress and reduces hypercholesterolemia
induced by iron overload in rats.
Lafay S, Gueux E, Rayssiguier Y, Mazur A, Remesy C, Scalbert A.
Unite des Maladies Metaboliques and Micronutriments, INRA de
Clermont-Ferrand/Theix, 63122 St-Genes-Champanelle, France.
The effects of caffeic acid, a major phenolic compound of the diet, on
oxidative stress and cholesterolemia are studied in rats submitted to
oxidative stress by iron overload. Male Wistar rats were fed
semi-synthetic diets containing regular (50 mg/kg diet) or high (2000
mg/kg) doses of iron with and without caffeic acid (6460 mg/kg) for 4
weeks. The high doses of iron induced an increase of lipid oxidation in
the liver, as measured by thiobarbituric acid-reactive substances
(TBARS), and an increase of cholesterolemia. Caffeic acid fully
prevented the pro-oxidant effects of high iron doses (p < 0.001). It
also reduced lipid peroxidation in rats fed the low iron dose (p <
0.05). Caffeic acid also increased vitamin E levels in plasma (2.74
micromol/L to 4.09 micromol/L for normal diet; p < 0.001; 2.78
micromol/L to 4.94 micromol/L for iron supplemented diet p < 0.001).
Iron-induced hypercholesterolemia was inhibited by caffeic acid (1.07
g/L to 0.82 g/L; p < 0.001). These results demonstrate the
antioxidative capacity of caffeic acid, a highly bioavailable
polyphenol, in an in vivo model of oxidative stress.
PMID: 15929632 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
|
| |
|
|