| Susie, age 9 2005-11-23, 12:49 am |
| In the 12/05 Emerging Infectious Diseases article titled "Central
African Hunters Exposed to Simian Immunodeficiency Virus,"
Kalish et al. (CDC's Thomas Folks is senior author) state:
"Our data, taken together with previous reports of high prevalence of
SIV in NHP bushmeat (6) and high levels of NHP exposure (3), offer new
evidence that persons who hunt and butcher wild NHPs are subject to
ongoing exposure and potential infection with SIV. In a study of 16 SIV
isolates from 5 different primate lineages, 12 were capable of infecting
human monocyte-derived macrophages, and 11 were capable of replicating
in human peripheral blood mononuclear cells (7), although cell tropism
does not necessarily predict virus pathogenicity. Productive crossover
infections may occur in low numbers in remote areas of Africa, but
because of low population density and isolation, they do not have the
opportunity to become epidemic strains and instead become dead-end
infections."
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http://www.cdc.gov/ncidod/EID/vol11no12/05-0394.htm
Emerging Infectious Diseases
Vol. 11, No. 12
December 2005
Central African Hunters Exposed to Simian Immunodeficiency Virus
Marcia L. Kalish,* Nathan D. Wolfe,? Clement B. Ndongmo,* Janet
McNicholl,* Kenneth E. Robbins,* Michael Aidoo,* Peter N. Fonjungo,*?
George Alemnji,? Clement Zeh,* Cyrille F. Djoko,§ Eitel Mpoudi-Ngole,?
Donald S. Burke,? and Thomas M. Folks*
*Centers for Disease Control and Prevention, Atlanta, Georgia, USA;
?Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland,
USA; ?Project IRECAM (Investigation of Retroviruses in Cameroon),
Yaoundé, Cameroon; and §Johns Hopkins Cameroon Program, Yaoundé,
Cameroon
Email: mkalish@cdc.gov
Abstract: HIV-seronegative Cameroonians with exposure to nonhuman
primates were tested for simian immunodeficiency virus (SIV) infection.
Seroreactivity was correlated with exposure risk (p<0.001). One person
had strong humoral and weak cellular immune reactivity to SIVcol
peptides. Humans are exposed to and possibly infected with SIV, which
has major public health implications.
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