Diabetes - Iron iron everywhere / diabetes

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Iron iron everywhere / diabetes

ironjustice@aol.com

2006-04-30, 12:52 am

RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes

Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links

Common presence of non-transferrin-bound iron among patients with type
2 diabetes.

Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider RC.

Department of Preventive Medicine, School of Medicine, Kyungpook
University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422.
lee_dh@knu.ac.kr.

OBJECTIVE: Recently, we reported increased cardiovascular disease
mortality among supplemental vitamin C users with type 2 diabetes in a
prospective cohort study. Because vitamin C may cause oxidative stress
in the presence of redox active iron, we hypothesized that
non-transferrin-bound iron (NTBI), a form of iron susceptible to redox
activity, may be present in patients with type 2 diabetes. RESEARCH
DESIGN AND METHODS: We measured serum NTBI levels using
high-performance liquid chromatography in 48 patients with known
diabetes (at least 5 years duration since diagnosis), 49 patients with
newly diagnosed diabetes, and 47 healthy control subjects (frequency
matched on age and sex). RESULTS: NTBI was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes.
Mean NTBI values varied significantly between the three groups, with
the highest values being observed in patients with known diabetes and
the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29 vs.
0.04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin
saturation were very similar among the three groups, yet NTBI was
strongly associated with serum total iron (r = 0.74, P < 0.01) and
percent transferrin saturation (r = 0.70, P < 0.01) among the patients
with known diabetes. CONCLUSIONS: Consistent with our hypothesis, these
data demonstrate the common existence of NTBI in type 2 diabetic
patients with a strong gradient with severity. Prospective cohort
studies are required to clarify the clinical relevance of increased
NTBI levels.

PMID: 16644642 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

sstrumello

2006-05-02, 10:52 am

I read the summary of this research (see
http://care.diabetesjournals.org/cg...tract/29/5/1090), and I
would not place too much weight on a study of 49 individuals and 47
controls. The FDA would require thousands to approve a pharmaceutical,
this is a small study with an interesting finding, but it is hardly
appropriate to call it a population-based study that is appropriate to
base medical decisions on.

ironjustice@aol.com wrote:
> RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
> diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes
>
> Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links
>
>
> Common presence of non-transferrin-bound iron among patients with type
> 2 diabetes.
>
> Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider RC.
>
> Department of Preventive Medicine, School of Medicine, Kyungpook
> University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422.
> lee_dh@knu.ac.kr.
>
> OBJECTIVE: Recently, we reported increased cardiovascular disease
> mortality among supplemental vitamin C users with type 2 diabetes in a
> prospective cohort study. Because vitamin C may cause oxidative stress
> in the presence of redox active iron, we hypothesized that
> non-transferrin-bound iron (NTBI), a form of iron susceptible to redox
> activity, may be present in patients with type 2 diabetes. RESEARCH
> DESIGN AND METHODS: We measured serum NTBI levels using
> high-performance liquid chromatography in 48 patients with known
> diabetes (at least 5 years duration since diagnosis), 49 patients with
> newly diagnosed diabetes, and 47 healthy control subjects (frequency
> matched on age and sex). RESULTS: NTBI was commonly present in
> diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes.
> Mean NTBI values varied significantly between the three groups, with
> the highest values being observed in patients with known diabetes and
> the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29 vs.
> 0.04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin
> saturation were very similar among the three groups, yet NTBI was
> strongly associated with serum total iron (r = 0.74, P < 0.01) and
> percent transferrin saturation (r = 0.70, P < 0.01) among the patients
> with known diabetes. CONCLUSIONS: Consistent with our hypothesis, these
> data demonstrate the common existence of NTBI in type 2 diabetic
> patients with a strong gradient with severity. Prospective cohort
> studies are required to clarify the clinical relevance of increased
> NTBI levels.
>
> PMID: 16644642 [PubMed - in process]
>
> --------------------------------------------------------------------------------
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

ironjustice@aol.com

2006-05-03, 12:52 am

>>I read the summary of this research (see
http://care.diabetesjournals.org/cg...tract/29/5/1090), and I

would not place too much weight on a study of 49 individuals and 47
controls. The FDA would require thousands to approve a pharmaceutical,

this is a small study with an interesting finding, but it is hardly
appropriate to call it a population-based study that is appropriate to
base medical decisions on.<<

Yes .. buuuuuut .. PREVIOUS studies have ALREADY been done ..
'guessing' .. at the outcome .. OF .. iron reduction.

Voila ..

Very good results ..

Br J Nutr 2001 Oct;86(4):515-9

Low iron status and enhanced insulin sensitivity in lacto-ovo
vegetarians.

Hua NW, Stoohs RA, Facchini FS

Department of Medicine, Division of Nephrology, San Francisco
General
Hospital, San Francisco, CA, USA.

[Medline record in process]

The efficacy of insulin in stimulating whole-body glucose disposal
(insulin sensitivity) was quantified using direct methodology in
thirty lacto-ovo vegetarians and in thirty meat-eaters. All subjects

were adult, lean (BMI <23 kg/m2), healthy and glucose tolerant.
Lacto-ovo vegetarians were more insulin sensitive than meat-eaters,
with a steady-state plasma glucose (mmol/l) of 4.1 (95 % CI 3.5,
5.0)
v. 6.9 (95 % CI 5.2, 7.5; respectively. In addition, lacto-ovo
vegetarians had lower body Fe stores, as indicated by a serum
ferritin
concentration (mg/l) of 35 (95 % CI 21, 49) compared with 72 (95 %
CI
45, 100) for meat-eaters To test whether or not Fe status might
modulate insulin sensitivity, body Fe was lowered by phlebotomy in
six
male meat-eaters to levels similar to that seen in vegetarians, with
a
resultant approximately 40 % enhancement of insulin-mediated glucose

disposal Our results demonstrate that lacto-ovo vegetarians are more

insulin sensitive and have lower Fe stores than meat-eaters. In
addition, it seems that reduced insulin sensitivity in meat-eaters
is
amenable to improvement by reducing body Fe. The latter finding is
in
agreement with results from animal studies where, no matter how
induced, Fe depletion consistently enhanced glucose disposal.

PMID: 11591239, UI: 21475355
_________________________________________________________________

Couple with the FACT giving iron to an animal CAUSES diabetes .. and by
REMOVAL of said iron .. the animals diabetes is .. CURED ..

<<snip>>
Repeated blood withdrawals from
ferric-nitrilotriacetate-treated {iron] animals resulted in
disappearance of
hypergycmia, glycosuria, ketonemia, and ketonuria; disappearance of
iron from the liver and pancreas; and restoration of islet beta
granules to the control level.
<<snip>>

http://tinyurl.com/h726a

Eh ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Ma¢k

2006-05-03, 12:52 am

On 2 May 2006 17:48:39 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> Huffed and Puffed the following into the madness
of usenet:

>'guessing' .. at the outcome .. OF .. iron reduction.
>
>Voila ..
>

now you know the sum total of Tom's medical experience.

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